Neuroscience Reconstructed: Proteomics

About This Course

Modern neuroscience is multidisciplinary and collaborative. We need to integrate knowledge of experimental and theoretical approaches to neuroscience, and look at the brain and brain function from different perspectives: for example, protein expression can partially explain differences in reading ability, but there is no single protein that makes someone a good or a poor reader. Protein expression depends on the regulation of genes, and their function can be influenced by external factors such as someone’s diet or a virus infection. So to understand something as complex as reading ability, we need to stitch together knowledge about the role of genes, proteins, cells, and large networks of cells.

In Neuroscience reconstructed: Neuroproteomics, we will focus on the basic biology of proteins, their role in the nervous system and as well as introduce you to the fields of translatomics, proteomics and their applications.

• week 1: Translation
• week 2: Protein maturation
• week 3: Main protein functions
• week 4: Translatome and proteome
• week 5: Methods and tools in neuroproteomics: mass spectrometry & structural biology
• week 6: Computational neuroproteomics
• week 7: Translational aspects: protein aggregates and neurodegeneration
• week 8: Modeling proteins

Each week will include a video lecture or reading material, practice exercises, online tools to access existing data as well as a reading list if you wish to learn more on the week's subject. The week will be concluded by a graded assignment.

You will learn from top scientists, specialised in each field, and have access to research databases and learning resources such as brain atlases and brain modeling tools. We aim to show you how these new tools can help integrate the vast amounts of neuroscience data available to innovate medical technologies and therapies. And we will teach you how to use these tools for your own research and understanding.