Here, you can find an overview of the articles discussed during the lectures and in the exercises, a list of general references such as textbooks and reviews as well as selected online tools and databases relevant to the course. For more references, databases and tools, we invite you to check the Additional information section available in the conclusion of each week.
Articles discussed in the course
- Epigenetic dysregulation of enhancers in neurons is associated with Alzheimer's disease pathology and cognitive symptoms, Nature communications 2019
- Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism, Cell 2020
- Epigenetic dysregulation of enhancers un neutrons is associated with Alzheimer's disease pathology and cognitive symptoms, Nature Communications 2019
- Architecture of the Mouse Nervous System, Cell 2018
- Rescue of the spinal muscular atrophy phenotype in a mouse model by early postnatal delivery of SMN, Nature Biotechnology 2010 (this article has been retracted since the recording of the lecture)
- Systemic gene delivery in large species for targeting spinal cord, brain, and peripheral tissues for pediatric disorders, Molecular Therapy 2011
- Single-dose gene replacement therapy for spinal muscular atrophy, New England Journal of Medicine 2017
- Hepatotoxicity following administration of onasemnogene abeparvovec (AVXS-101) for the treatment of spinal muscular atrophy, Journal of Hepatology 2020
- Gain of toxic function by long-term AAV9-mediated SMN over expression in the sensorimotor circuit, Nature Neuroscience 2021
General References
- Developmental Biology, (6th edition), Sinauer Associates 2000
- Molecular Biology of the Cell (4th edition), Garland Science 2002
- Epigenetics learning centre
- Milestones in genomic sequencing, Nature Milestones 2021
- The OMICs: Applications in Neuroscience, Oxford University Press 2013
- Coming of age: ten years of next-generation sequencing technologies, Nature Reviews Genetics 2016
- The rapidly evolving state of gene therapy, The Journal of the Federation of American Societies for Experimental Biology, 2018
- Putting big data to good use in neuroscience, Nature Neuroscience 2018
- Neuronal dynamics: From single neurons to networks and models of cognition, Cambridge University Press 2014
- Reconstruction and simulation of neocortical microcircuitry, Cell 2015
Tools and databases
- The Mouse brain atlas is a genome-wide atlas of gene expression throughout the adult mouse brain.
- The Genome Browser is a collection of vertebrate and model organism genome assemblies and annotations, along with a large suite of tools for viewing, analyzing and downloading data.
- The eMouse Atlas is a detailed model of the developing mouse that provides information about the shape, anatomy and histological structure of the mouse embryo.
- STAR is an RNA sequence aligner.
- BrainBase is a curated knowledgebase for brain diseases that features disease-gene associations that can help selecting gene therapy candidates.
- The Gene Ontology provides a computational representation of the current knowledge about the function of genes.
- The Blue Brain Cell Atlas describes the number, types and positions of cells in all areas of the mouse brain.
- Neocortical Microcircuit Collaboration Portal gives access to a browser of a reconstructed microcircuit, simulation videos, experimental data and models.